Master of Science in Clinical Investigation Courses

  • Introduction to Clinical Epidemiology | CTS 605A

    Programs: MS in Clinical Investigation, Pathway to Graduate Study

    This course reviews basic principles of epidemiology, investigation of disease outbreaks, and the application of various observational and experimental research designs and strategies to clinical, epidemiological, and translational research. Didactic instruction, readings, and problem sets (including lab-based analyses) are utilized to more fully understand epidemics and their causes, as well as various study designs including cross-sectional studies, case-control studies, cohort designs, and randomized clinical trials. Students also will learn how to design surveillance systems and develop and evaluate screening and diagnostic tests. Students are graded on in-class participation and 2 writing assignments (write-up of lab exercise and in-class student presentation). This will be a full semester course with a total of 30 contact hours.

    Course Coordinator: Robert Goldberg

    Semester Offered: Fall

    Last Taught: Fall 2015

  • Grant Writing | CTS 606

    Programs: MS in Clinical Investigation

    This course is designed to familiarize trainees with the grants review process and each of the NIH grant proposal requirements. The course will include detailed overviews of the grant process, participation in several mock proposal review sessions, and completion of each of the written components of a grant including specific aims, background and significance, preliminary studies, and design methods. Students should invoke their mentor in the development of their grant proposal to the extent possible.

    Course Coordinator: Robert Goldberg

    Semester Offered: Fall, Spring, Summer

    Last Taught: Has not been taught within past tow years

  • Biomedical Informatics | CTS 607

    Programs: MS in Clinical Investigation

    This course offers an overview of the field of biomedical informatics. In this course, concepts from computer and information science are combined with current issues in research, training and clinical practice. The course will provide a broad overview of electronic health records, decision support systems, standards, security and confidentiality, evidence-based medicine, information retrieval, bioinformatics, public health informatics, imaging informatics, and consumer health informatics.

    Course Coordinator: Ralph Zotolla

    Semester Offered: Fall

    Last Taught: Has not been taught within past two years

  • Team Science | CTS 608

    Programs: MS in Clinical Investigation

    Students will learn how to create and sustain cohesive research teams, develop a productive program of research, develop good mentor and mentee relationships, engage in transdisciplinary science, understand the NIH Roadmap, and hear about different forms of clinical and community research from local investigators who conduct it.

    Course Coordinator: Sherry Pagoto

    Semester Offered: Spring

    Last Taught: Spring 2015

  • Design of Observational Studies and Clinical Trials | CTS 609

    Programs: MS in Clinical Investigation

    The course considers the scientific and practical considerations in the design and conduct of observational studies and clinical trials. Topics to be covered include: study designs (cohort studies, case-control studies, and clinical trials), confounding and bias, ethical considerations, patient recruitment and retention, interim analysis and safety monitoring, and analysis and reporting. Course objectives will be met through a combination of lecture, discussion, and development of a proposal in the student’s area of interest.

    Course Coordinator: Bruce Barton

    Semester Offered: Spring

    Last Taught: Spring 2015

  • Topics in Molecular Medicine | CTS 610

    Programs: MS in Clinical Investigation

    This course covers a variety of current topics centered on specific diseases with a molecular aspect to either diagnosis or treatment. The course is aimed at developing skills necessary for understanding and discovering how changes in gene function can cause human disease. The course includes a series of topics that use inherited disease processes to illustrate the physiological consequences of molecular, celluar, and genetic phenomena. The course emphasizes the acquistion of skills in interpreting scientic literature and synthesizing this knowledge with real-world patient care. In this way, students learn interesting state-of-the-art material while developing skills and expertise in integrative biology and molecular medicine.

    Course Coordinator: John Sullivan

    Semester Offered: Spring

    Last Taught: Has not been taught within past two years

  • MSCI Scientific Writing | CTS 611

    Programs: MS in Clinical Investigation

    This course teaches students how to develop a peer reviewed scientific manuscript, through the review of elements of style, authorship, and extent of information that needs to be incorporated into a scientific research paper. Students will learn how to develop the elements that go into a successful scientific manuscript, submit an article for peer review and respond to reviewers' concerns. During each session, students will critique the work of others enrolled in the course to obtain hands on experience in the write-up of the introduction, methods, results, and discussion sections of a manuscript. This course will also teach students how to put together a successful oral, as well as poster, scientific presentation.

    Course Coordinator: Robert Goldberg

    Semester Offered: Fall

    Last Taught: Fall 2015

  • Introduction to Biostatistics in Clincial Research | CTS 612A

    Programs: MS in Clinical Investigation

    This course will cover the basic elements of biostatistics as applied in clinical research. It will provide the students with the knowledge to read and understand journal articles, understand different study designs, and understand the basics of statistical analysis.

    Course Coordinator: Louise Maranda

    Semester Offered: Fall

    Last Taught: Has not been taught withing past two years

  • Applied Biostatistics | CTS 612B

    Programs: MS in Clinical Investigation

    This course will build on the basic elements of biostatistics, teaching the design elements, analysis approaches, and methods of presentation for: surveys, case-control studies, cohort studies, and randomized clinical trials. Students will also develop the capability to critically evaluate the published scientific (and commercial) literature.

    Course Coordinator: Louise Maranda

    Semester Offered: Spring

    Last Taught: Has not been taught within past two years

  • Clinical & Translational Research Seminar | CTS 620

    Programs: MS in Clinical Investigation

    This course introduces Clinical Translational Research Pathway students in the optional elective in SOM to principles, theory, background and skills required for clinical and translational research. Seven required seminars plus attending a Human Subjects IRB meeting occur in MS1 and there are 6 additional contact hours and a paper required in MS2. Thus course requires participation in approximately 22 contact hours beyond medical school coursework, plus the 10-20 hour CITI certificate.

    Course Coordinator: Catarina Kiefe

    Semester Offered: Fall, Spring

    Last Taught: Has not been taught within past two years

  • Ethics for Clinical Research | CTS 702

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    This course is designed to prepare students with basic knowledge of ethics and understanding and addressing problems in the ethical conduct of research and understanding and addresssing scientific misconduct, including fraud, misrepresentation, conflict of interest. The course also addresses authorship guidelines, IRB regulations and UMASS Medical School regulations. Students will also focus on how to design ethical research, evaluating treatment risk, placebo control, ethics of recruitment, dilemmas of informed consent, potential scientific contribution and issues for special populations and conducting research internationally.

    Course Coordinator: Catherine Dube

    Semester Offered: Fall

    Last Taught: Fall 2015

  • Quantitative Methods to Improve Health | CTS 703

    Programs: MS in Clinical Investigation

    The structure of this course will be in modules, with didactic teaching followed by discussion of assigned weekly reading. The introductory lecture will provide a brief overview of outcomes and effectiveness research; and explain how the subsequent four course modules will provide some of the basic tools in this field. These are the most important tools required to produce the knowledge that will allow us to change health care and the health care system.

    Course Coordinator: Catarina Kiefe

    Semester Offered: Spring

    Last Taught: Has not been taught within past two years

  • Genomics | CTS 709

    Programs: MS in Clinical Investigation

    This course provides an introduction to the field of genomics. It will cover the structure of the genome, the strategies that were utilized to map and sequence the genome, and will consider in detail how genomic sequence information is utilized for paharmacogenomics, drug discovery and diagnostics. The course also introduces post-genomics technologies including bioinformatics, functional genomics, and proteomics. The course will also emphasize new genomic technologies, high throughput sequencing, genome-wide studies, methodologies and interpretations and gene expression/microarrays.

    Course Coordinator: Richard Baker

    Semester Offered: Fall

    Last Taught: Has not been taught within past two years

  • Randomized Clinical Trials in Behavorial Medicine Research | CTS 717

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    The purpose of this course is to provide opportunities for the student to understand the foundations of randomized clinical trials (RCTs) in behavorial medicine research. Topics related to theory, design, implementation, and evaluation of behavioral randomized clinical trials will be discussed. Students will develop a research project where concepts can be applied and practice reviewing behavioral RCTs in the published literature.

    Course Coordinator: Sherry Pagoto

    Semester Offered: Summer

    Last Taught: Summer 2014

  • Designing and Conducting Health Surveys | CTS 719

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    This course introduces students to the foundations of survey methods. The course is designed to introduce students to the use of surveys in public health. Self-reported data, collected using various survey methods, are used to estimate behavioral risks, disease prevalence, access to medical care, health literacy, and physical activity. For example, the CDC sponsors The Behavioral Risk Factor Surveillance System (BRFSS), a telephone survey conducted by U.S. state health departments. The BRFSS provides state-specific information about issues such as asthma, diabetes, health care access, alcohol use, hypertension, obesity, cancer screening, nutrition and physical activity, tobacco use, and more.

    Course Coordinator: Carole Upshur

    Semester Offered: Summer, odd years

    Last Taught: Has not been taught within past two years

  • Infectious Disease Epidemiology | CTS 721

    Programs: Clinical & Population Health Research, Immunology & Microbiology, MS in Clinical Investigation

    This course is designed to provide a historical perspective on infectious disease epidemiology as a basis for understanding current global health research and programs aimed at disease control, elimination, eradication and extinction. A passing grade will be based on class participation, discussing required readings and a final written (take-home) report.

    Course Coordinator: Ann Moormann

    Semester Offered: Spring

    Last Taught: Has not been taught within past two years

  • Principles of pharmacology | CTS 722

    Programs: MS in Clinical Investigation

    Students will learn to a) apply the scientific method and an understanding of the Principles of Pharmacology (pharmacokinetics, pharmacodynamics, drug metabolism, drug interactions, autonomic nervous system) to the practice of evidence-based medicine; b) apply an understanding of the Principles of Pharmacology in the making of treatment decisions and c) will have the tools to continue life-long learning and self-assessment with respect to the Principles of Pharmacology, including appropriate utilization of pharmaceuticals and prescribing practice.

    Course Coordinator: Charles Sagerstrom

    Semester Offered: Fall

    Last Taught: Has not been taught within past two years

  • Cancer Concepts | CTS 723

    Programs: MS in Clinical Investigation

    This course will cover the basic pathophysiology of malignancy, with each concept introduced by or tied back to one or more specific clinical cases. The course will utilize a combination of lectures and small group either precepts, in which students discuss assigned reading with the assistance of a faculty preceptor, or virtual laboratories, in which students will use computer images of the pathology and the 3 dimensional anatomy of malignancy to understand the process at the cellular, tissue, organ and organism levels. In addition, introductions will be provided to the 3 clinical disciplines of oncology and to the epidemiology and societal implications of cancer.

    Course Coordinator: James Liebmann

    Semester Offered: Spring

    Last Taught: Spring 2013

  • Introduction to the U.S Healthcare System: How Policies and Practice Affect Health | CTS 725

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    This course provides an in-depth look at the US healthcare system. Students will apply constructs of structure, process, and outcomes of care to understand and evaluating health care quality and cost and learn how health care policies and payment practices impact the accessibility, effectiveness and cost of care.

    Course Coordinator: Robin Clark

    Semester Offered: Fall, odd years

    Last Taught: Fall 2015

  • Design and Conduct of Studies of Chronic Disease | CTS 726

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    The course will discuss fundamental concepts in chronic disease epidemiology, common research methods used in the design and conduct of studies of chronic disease epidemiology, and the application of these methods for the major chronic diseases affecting industrialized countries. Topics will include cardiovascular disease, cancer, cerebrovascular disease, diabetes, and lifestyle practices to promote health.

    Course Coordinator: Robert Goldberg

    Semester Offered: Fall, odd years

    Last Taught: Fall 2015

  • Use of Existing Population-Based Public Health and Health Care Data | CTS 727

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    Students will become familiar with existing population-based public health, electronic medical record, and claims data. Topics include advantages and disadvantages, complex sampling and weighting, and obtaining limited-access data. Using a population-based dataset, students will develop and implement an analytic plan to answer a research question of their choosing.

    Course Coordinator: Molly Waring

    Semester Offered: Spring, even years

    Last Taught: Spring 2014

  • Social Epidemiology | CTS 729

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    We will cover the main societal causes implicated in affecting the health of human populations, including hierarchy, racism, gender hierarchy, heteronormativity, and ableism. We will focus on methodological approaches to measuring and interpreting these forces and their effects, on both minority and dominant populations.

    Course Coordinator: William Jesdale

    Semester Offered: Spring, even years

    Last Taught: Spring 2014

  • Behavioral Determinants | CTS 731

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    The purpose of this class is to learn models of disease prevention, multi-level determinants of health behaviors, and major theories of health behavior change and their application to interventions to address major public health problems.

    Course Coordinator: Milagros Rosal

    Semester Offered: Fall, even years

    Last Taught: Fall 2014

  • Qualitative Methods for Health Research | CTS 732

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    This course examines uses of qualitative methods in mixed-qualitative or mixed-qualitative/quantitative health studies. Essential qualitative research components are explored: study community; theory; rigor; research questions; data collection methods; writing open-ended questions; sampling; data analysis; publishing; and writing proposals. Students apply concepts covered in class by collecting data for written assignments.

    Course Coordinator: Kate Lapane

    Semeter Offered: Spring, odd years

    Last Taught: Spring 2015

  • Pharmacoepidemiology | CTS 733

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    The purpose of this class is to learn pharmacoepidemiology, including: rigorous methodologic approaches to the measurement of medication exposure, adherence and adverse events; pharmacoepidemiologic study design; choices for pharmacoepidemiology data resources; and the role of quality of life measurements and pharmacoeconomics.

    Course Coordinator: Jennifer Tjia

    Semester Offered: Summer, odd years

    Last Taught: Summer 2015

  • Place and Health | CTS 734

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    In this class, we will explore the influence of “place” on population health, including physical environment (e.g. air, water, soil, food), built environment (e.g. neighborhood structure, traffic, green space), social environment (e.g. cohesion, safety, deprivation, segregation), and legal and civic structure (e.g. policy, law, representation). We will also learn to implement (and critique) methodologic approaches that are particularly adapted to understanding how individuals and places interact, specifically multilevel thinking and modeling, and spatial analytic methods.

    Course Coordinator: William Jesdale

    Semester Offered: Summer, Fall, odd years

    Last Taught: Fall 2015

  • Introduction to Implementation Science: Moving Research into Practice in Healthcare and Community Settings | CTS 735

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    This class provides an introduction to what is often referred to as translational, dissemination, or implementation research, as well as the broad field of implementation science. Students will learn about the significance and major initiatives associated with moving research into practice, and will be introduced to conceptual and analytic tools (e.g., theories, frameworks) to support work in this area.

    Course Coordinator: Timothy Hogan

    Semester Offered: Fall

    Last Taught: Fall 2015

  • Conducting Implementation Research: Designing and Executing Studies for Moving Research into Practice in Healthcare and Community Settings | CTS 736

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    This class builds on the foundation offered in CTS 735 regarding salient concepts and theories in the field of Implementation Science to examine key issues in the design and conduct of implementation research. Students will learn about prominent study designs that characterize many implementation trials, the important role that formative assessment plays in informing implementation efforts and the issues inherent in identifying and measuring appropriate implementation processes and outcomes.

    Course Coordinator: Timothy Hogan

    Semester Taught: Spring

    Last Taught: New course to be taught Spring 2016

  • MSCI Independent Study | CTS 801

    Programs: MS in Clinical Investigation

    The purpose of an independent study elective is to gain in depth knowledge of a specific topic by working closely with a faculty member with expertise in that area. Typically independent studies cover areas not addressed in the core curriculum and advanced topics or other electives. In the present independent study, will work with the faculty mentor/advisor to explore research content areas, as welll as methodologies, that have not been previously covered in core curriculum courses. The time spent in this elective will be equivalent to 2 credit hours.

    Course Coordinator: Rob Goldberg

    Semester Offered: Spring, Summer

    Last Taught: Spring 2015

  • MSCI Journal Club | CTS 802

    Programs: MS in Clinical Investigation

    This journal club provides a forum in which students will discuss current articles and be introduced to advanced methods. Through readings, presentations and discussion, wtudents will deepen their understandinng of methods critical for clinical investigation and strengthen their data presentation and writing skills.

    Course Coordinator: Robert Goldberg

    Semester Offered: Fall, Spring, Summer

    Last Taught: Fall 2015

  • MSCI Research Seminar | CTS 855

    Programs: MS in Clinical Investigation

    This is an ongoing seminar series offered on a monthly basis throughout the academic year that will be led by individual senior scientists who will discuss their clinical, public health, and translational sciences research. This seminar series will provide trainees with exposure to a wide variety of potential research mentors as well as topic areas to further explore for their thesis research and beyond.

    Course Coordinator: Robert Goldberg

    Semester Offered: Fall, Spring, Summer

    Last Taught: Has not been taught within past two years

  • CTS TRAC Meeting | CTS 865

    Programs: Clinical & Population Health Research, MS in Clinical Investigation

    All Graduate Students are required to have a TRAC meeting each academic year in the fall. After passing their Qualifying Exam in January of the second year, and the Thesis Proposal Defense in the Spring or summer of second year, students are required to register for this course each Fall semester until their Dissertation Examination Committee is formed.

    Course Coordinator: Kate Lapane

    Semester Offered: Fall Spring

    Last Taught: Course taught every year

  • MSCI Pre-Thesis Research | CTS 871

    Programs: MS in Clinical Investigation

    This is for 1st year students who have selected a Thesis Advisor but who have not yet had their thesis research proposal passed by their committee

    Course Coordinator: Student's Thesis Advisor

    Semester Offered: Fall, Spring, Summer

    Last Taught: Taught every semester

  • MSCI Thesis Research | CTS 901

    Programs: MS in Clinical Investigation

    Students register for Thesis Research after pasing their Master's thesis proposal. They will take Thesis Research each semester until they have completed and defended their thesis project.

    Course Coordinator: Student's Thesis Advisor

    Semester Offered: Fall, Spring, Summer

    Last Taught: Taught every semester

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