Section: Rotations

Postdoctoral Position Available

Victor Boyartchuk, Ph.D.

Academic Role: Assistant Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology
   Program in Gene Function and Expression

Other Affiliation(s):
   Center for AIDS Research
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

Potential Rotation Projects

1. Analysis of the role of CXCL11 in control of bacterial infections.

CXCL11 is a chemokine that in addition to mediating T cell signaling has demonstrated defensin-like bactericidal activity. Mouse strains that differ in sensitivity to L. monocytogenes infection carry different alleles of CXCL11. The goal of the project is to characterize the role of CXCL11 in the course of L. monocytogenes infection and establish the effect of CXCL11 mutations of the outcome of infection.

2. Analysis of Type I interferon induction by L. monocytogenes.

Intracellular L. monocytogenes is capable of inducing IFNb expression that in turn contributes to suppression of innate immunity. We identified inbred mouse strains that in response to L. monocytogenes infection differ in the degree of IFNb induction. We are currently in the process of evaluating candidate genes that determine these differences. The goal of the project is to evaluate polymorphisms in individual candidate genes identified by a combination of genetic mapping and expression profiling experiments.

Office: 523/LRB
Phone: 508-856-4353
E-mail: Victor.Boyartchuk@umassmed.edu
Keywords: Genetic Systems, Animal Models of Disease, Infectious Disease

More on Victor Boyartchuk's Research Research | Publications | Rotations | Personnel | Biography View All Sections on One Page

Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Victor Boyartchuk for additional details.