Section: Rotations

Jason J. Chen, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Medicine

Other Affiliation(s):
   Center for AIDS Research
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

Potential Rotation Project

Role of cell cycle-related proteins in E6-induced polyploidy. Through genetic and molecular approaches, we will determine the role and mechanism by which the cell cycle-related proteins abrogates the postmitotic checkpoint in E6 expressing cells.

Role of anti-apoptotic proteins in cervical carcinogenesis. The goal of this project is to understand the role of anti-apoptotic proteins in the development of cervical cancer.

Mechanism underlying HPV E7-induces re-replication. Through biochemistry and molecular approaches, we will determine the extent to which DNA replication initiating factors are required for HPV-E7 to induce re-replication.

Identification and characterization of cervical stem cells. Using known markers combined with functional assays, we will identify and characterize stem cells from cervix and examine their role in tumorigenesis.

Office: LRB 323
Phone: 508-856-1857
E-mail: Jason.Chen@umassmed.edu
Keywords: Stem Cell Biology, Cancer Biology, Apoptosis, Virology, Cell Cycle

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