Funded Active Studies

Steven Bird, MD 
NIH (R21 NSD070306) Bird (PI) 9/30/2011- 8/31/2013 
Novel Neuromuscular Protection to Counter Act Organophosphorus (OP) Poisoning. The purpose of this grant is to determine the physiologic and electromyographic efficacy of the nicotinic receptor antagonist rocuronium in preserving NMJ function and NMJ architecture in novel minipig models of dimethoate and parathion poisoning. 
Role: Principal Investigator 

Edwin Boudreaux, PhD 
NIH/NIMH (U01 MH088278) Boudreaux (PI) 9/30/2009-5/31/2014 
Emergency Department Patient Safety and Follow-up Evaluation (EDSAFE). This research program will develop and test a standardized approach to screening emergency department (ED) patients for suicide risk; refine and test an ED-initiated intervention to reduce suicidal behavior and associated morbidity and mortality among people who self-identify or screen positive for suicidal ideation; and, complete a comparative economic analysis of treatment as usual, screening, and the intervention. 
Role: Principal Investigator 

NIH/NIMH (R42 MH078432) Boudreaux (PI) 9/20/2006-6/30/2013 
Mental Health Assessment and Dynamic Referral for Oncology (MHADRO) Phase 2. This Phase 2 STTR builds upon the Phase 1 MHADRO. It uses a randomized controlled trial design with a mixed cancer patient sample to assess the MHADRO’s effectiveness at identifying psychological distress, facilitating mental health treatment initiation, and reducing psychological distress. 
Role: Principal Investigator 

NCI (R01CA156699-01A1) Bock (PI) 8/19/2011-6/30/2016 
System-based Tracking and Treatment for Emergency Patients who Smoke: STTEP. A translational study to institute tobacco treatment following US PHS guidelines into existing electronic medical tracking software that is widely used across the United States. Adapt an existing Emergency Department Information Systems (EDIS) to facilitate the identification of smokers, prompt physician intervention enhance the provision of smoking cessation intervention materials as discharge instructions, facilitate quit-smoking medication prescription and advice, and connect the patient to follow up care through their primary care provider and a pro-active telephone quit line. 
Role: Co-Investigator 

NIH/NIAAA (1R41AA022035-01) Boudreaux (PI) 9/25/2012-2/28/2014 
The Remote Brief Intervention and Referral to Treatment service for alcohol (R-BIRT) will create a tele-health delivered model for alcohol brief intervention and referral to treatment. 
Role: Principal Investigator 

American Foundation for Suicide Prevention Betz (PI) 10/1/2011-9/30/2013 
Lethal means restriction for suicide prevention: Beliefs and behaviors of emergency department providers. The goals of this project are to describe the behaviors of Emergency Department (ED) physicians, nurses and other staff in relation to suicide prevention and “means restriction”—limiting access to firearms and other highly lethal methods of suicide—and to examine how these behaviors are affected by the implementation of a suicide assessment and intervention program for ED patients. Role: Co-Investigator 

Edward Boyer, MD 
NIH (R01DA033769) Boyer (PI) 5/1/2012-4/30/2014 
iMStrong, an innovative remote monitoring system for detecting cocaine use. “iMStrong”, a remote monitoring system that uses stat-of-the-art technologies to identify the onset and duration of cocaine use in cocaine-dependent patients under treatment. Specific aims are: 1) Technology deployment: To deploy and test a mobile technology for the remote identification of cocaine use episodes; and 2) Technology evaluation: To evaluate experience with the developed technology to understand the barriers and facilitators of technology utilization with a specific focus on detection of cocaine use as well as mechanisms of action that might underlie the quality of the patient-technology relationship. iMStrong will not only identify the onset and duration of episodes of cocaine use, it will obtain formative information on temporal events surrounding relapse. iMStrong’s collection of continuous data regarding the timing, location, contexts, and durations of cocaine use in individuals under treatment will advance drug abuse treatment research by providing a new capability to demonstrate efficacy of drug abuse interventions. 
Role: Principal Investigator 

NIH NIDA (1R01DA031081-01A1) Boyer (PI) 9/15/2011-7/31/2015 
A Mobile, Personalized Intervention with Real-Time Adaptation to HAART Adherence. Develop and test iHAART (“i♥”), a Smartphone application that delivers personalized interventions with content and dose that adapts in real time to variable HAART adherence in HIV+ stimulant users. 
Role: Principal Investigator 

Chad Darling, MD 
NIH/NHLBI (K23HL101991) Darling (PI) 8/15/2010-5/31/2015 
Acute decompensated heart failure: treatment timing and effects on outcomes. This study will conduct a prospective, observational study of the ED management of patients with ADHF in order to investigate the impact that the ED has on various clinical outcomes such as inpatient length of stay (LOS). 
Role: Principal Investigator 

John P. Haran, MD 
Joseph P. Healy Endowment Grant Haran (PI) 2/27/2012-5/28/2013 
Cytokine Production in the Acute Phase of Illness as Predictor of Disease Severity and Complications in Patients Presenting to the Emergency department with Influenza like Illness during the Influenza Season. To test the hypothesis that cytokine levels during acute infection differ from patients with a bacterial infection when compared to influenza infected individuals and to test that hypothesis that the pandemic influenza infection caused a different cytokine profile compared to seasonal influenza. 
Role: Principal Investigator 

Mary Elise Manuell, MD 
MA DPH (RFR# 008414) Manuell (PI) 7/1/2012-6/30/2013 
Massachusetts DPH Emergency Preparedness Education and Training Centers. The grant supports the development and implementation of a training center which will assess, develop, provide, coordinate and evaluate competency-based emergency preparedness education and training utilizing an all-hazards approach. 
Role: Principal Investigator 

Marie Mullen, MD and Adam Darnobid, MD 
Air Medical Physician Association Mullen & Darnobid (PI) 4/18/2012-9/30/2013 
The Use of Non-Invasive Hemodynamic Monitoring in Flight. The study will evaluate the use of the Non-Invasive Cardiac Output Monitor (NICOM) device in the critical care transport environment. 
Role: Co-Principal Investigator(s) 

Benjamin Terry, MD, MPH and Romolo Gaspari, MD, PhD 
UMMS Office of Global Health Terry (PI) 8/1/2012-7/31/2013 
Global Emergency Care Collaborative (GECC). The GECC strives to create quality sustainable emergency care systems in resource-limited settings that traditionally have lacked these services. The foreign partner in this project is the Nyakibale Hospital in Rukungiri, Uganda. 
Role: Co-Principal Investigator(s) 

Jeanine Ward, MD 
McNeil Consumer Health Care Sponsor-Investigator Study Ward (PI) 9/13/2012-5/31/14 
MicroRNA Profiles in Acetaminophen. 
Role: Principal Investigator 

Unfunded Active Studies 

Mark Bisanzo, MD 
US Utilization and accuracy by non-physician emergency care workers in Uganda a prospective randomized trial of health care workers in an Emergency Department in Uganda comparing standard educational (intermittent lectures) and a web based educational review of ultrasound images. The primary outcome is ultrasound proficiency and the secondary outcome is number of ultrasounds performed. 
Role: Principal Investigator 

Database review of patient outcomes at a rural Ugandan ED. 
Role: Principal Investigator 

John Broach, MD, MPH, MBA 
Facial Recognition in MCI. In collaboration with Medical Informatics Division to determine if commercially available facial recognition software can aid in victim identification following a Mass Casualty Incident. 
Role: Principal Investigator 

National Disaster Medical System Database Review; this review is to suggest data collection for future disasters with NDMS response. 
Role: Principal Investigator 

Adam Darnobid, MD, Stacy Weisberg, MD, and Michael Arce, MD 
Comparison of direct laryngoscopy to video laryngoscopy in a physically constrained environment of a helicopter. 
Role: Principal Investigators 

Adam Darnobid, MD, Stacy Weisberg, MD, and Ashley Larrimore, MD 
Field intubations by hospital based EMS providers- a comparison of national data. 
Role: Principal Investigators 

Romolo Gaspari, MD, PhD 
Bedside Ultrasound and Cardiac Arrest. UMASS is the coordinating site for a 36 national site prospective observation study determining if there are elements of echo that predict survival following cardiac arrest. 
Role: Principal Investigator 

Chest Wall Ultrasound in Trauma. A prospective randomized trial of patients with chest wall trauma. We are comparing the sensitivity and specificity of 2 different imaging protocols. 
Role: Principal Investigator 

Soft Tissue Characteristics of MRSA. A retrospective observational study designed to determine if there are specific image
 elements 
of abscess ultrasounds that are associated with MRSA. 
Role: Principal Investigator 

Sonographic features of pediatric soft tissue abscesses. A retrospective review of soft tissue ultrasounds comparing the features of pediatric patients and adult patients to determine if the sonographic characteristics are similar. 
Role: Principal Investigator 

Utility of sonographic features of cellulitis in determining failure of therapy. A prospective observational study of patients with cellulitis treated with outpatient antibiotics to determine if any of the sonographic features in these patients are associated with failure of therapy. 
Role: Principal Investigator 

Educational learning curves of Bedside Ultrasound. This is a retrospective review of 56000 ultrasounds performed over the last 8 years at UMASS to determine if there is a specific number of ultrasound imaging needed for proficiency in bedside ultrasound. 
Role: Principal Investigator 

John P. Haran, MD 
Antibiotic-Associated Diarrhea in Emergency Department Patients Discharged Home on Antibiotics. The main purpose of this study is to determine prospectively the frequency of antibiotic-associated diarrhea (AAD) in a large sample of patients discharged from the emergency department. Our hypothesis is that the rate of AAD will be similar to those of patients that have received antibiotics in the hospital, the setting from which the majority of AAD data has been gathered. 
Role: Principal Investigator 

Antibody Profile to Influenza Virus in Emergency Department Patients. The main purpose of this study is to describe the antibody profile to H1N1 influenza in the general population that visits the Emergency Department for care. This will include patients that are there for an acute respiratory complaint which may be influenza related, or who are there for any other complaint. Our hypothesis is that an individual’s antibody profile will be affected by factors such as age, vaccine and illness history and medical co-morbidities. Through this study we will hope to identify key factors which influence influenza antibody production and thus might aid in future vaccine programs strategies of who to target for vaccination. 
Role: Principal Investigator 

Dr. Haran will be starting up a project with a medical student looking at decision making strategies for patients with community acquired pneumonia. This project is still under early development. 
Role: Principal Investigator 

Melissa Leming, MD 
Ultrasound assisted triage during mass casualty incidents. Study of the use of ultrasound to augment secondary triage in Mass Casualty Incidents. 
Role: Principal Investigator 

Mass Casualty triage. A study to determine if just in time training could assist with triage in a MCI. 
Role: Principal Investigator 

Mary Elise Manuell, MD 
Pictorial Representations of Medical Procedures to Train for Effective Recall: Charles River Analytics. This study, sponsored by the US Army, is investigating whether a novel approach to training, using visual mnemonics and a micro game-based delivery platform (“Pictorial Mnemonic Games”), will produce better learning outcomes compared to a traditional alternative training method, in which soldiers study the same subject matter in the Soldier’s Manual of Common Tasks (“Traditional Soldier’s Manual”). 
Role: Principal Investigator 

Andrew Milsten, MD 
Hurricane data related to Gross Domestic product. Data is being reviewed to see correlation between impact of a hurricane and Gross Domestic Product of various countries. 
Role: Principal Investigator 

Marie Mullen, MD 
Observation of Minimally-invasive Cardiovascular Hemodynamic Optimization (MiCHO) with Early Goal-Directed Therapy (EGDT) in the Management of Severe Sepsis and Septic Shock Patients Presenting to the Emergency Department. It is comparing central venous pressure (CVP) measurements in septic shock patients with concomitant Esophageal Doppler measurements. The goal is to see if the CVP values and the Doppler values are equivalent. 
Role: Principal Investigator 

Joseph Tennyson, MD and Adam Darnobid, MD 
Time Saved with Lights and Siren use in an Urban EMS System. Comparing a patient transport with warning lights and siren with a “placebo” transport (EMS vehicle without a patient) at the same time, using the same route, without warning devices. 
Role: Principal Investigators 

Provider Perception of Clinical Utility of Transport with Lights and Siren. To determine the attending emergency physician's opinion regarding the use of warning lights and siren and its effect on this particular patient's outcome. 
Role: Principal Investigators 

Knowledge and beliefs of EMS providers towards lights and siren transportation- A survey. 
Role: Principal Investigators 

Joseph Tennyson, MD and Stacy Weisberg, MD 
Altitude-Related Change in ETT Cuff Pressure and Helicopter Emergency Medical Services (HEMS). An investigation into the effect of changes in altitude and helicopter emergency medical services on the pressure within the air filled cuff of an endotracheal tube. 
Role: Principal Investigators 

Evaluation of NEXUS Tool in the Prehospital Environment. An analysis of prehospital personnel's ability to accurately apply the NEXUS criteria for cervical spine clearance. 
Role: Principal Investigators 

Gregory Volturo, MD 
Behavioral Health (BH) patients boarding in Emergency Departments in Massachusetts. A ten Hospital retrospective chart review over a 2 week period in time of BH patients boarding in Massachusetts EDs. This project is designed to accurately identify the state of BH boarding in Massachusetts. The results of this project will hopefully identify the root causes of BH boarding in our State. 
Role: Principal Investigator 

Paul Zgurzynski, MD 
Teaching to the Level of the Learner. The study involves a needs assessment on faculty perceptions on teaching to different levels of learner (med student-resident) and then doing a faculty intervention (already done) and observing baseline teaching effectiveness (already done)Currently, we need to perform a faculty development using on increasing teaching effectiveness then re-surveying learners. This is ongoing at 3 other sites Albany, Brown, and Maimonides. 
Role: Principal Investigator