"Scientists at UMass Medical School have shown that diffuse large B-cell lymphoma (DLBCL) may be susceptible to treatment by re-activating the normal aging program in tumor cells so they can no longer divide. The study, published in Nature Communications, details a novel tumor-suppressive role for the Smurf2 protein—which typically plays an “enforcer” role in cellular aging, also called senescence—in a subset of DLBCL. Identification of this novel function for Smurf2 provides a new therapeutic target for treating this cancer."
To read more about this article visit the UMMS News website: http://www.umassmed.edu/news/2013/research/activating-aging-in-tumor-cells-may-be-effective-against-lymphoma.aspx
To learn more about the Zhang Lab in the Department of/news/news-archives/2013/10/activating-aging-in-tumor-cells-may-be-effective-against-lymphoma/ and Developmental Biology visit: http://www.umassmed.edu/cellbio/zhanglab/index.aspx