Faculty by Rank

Professors | Associate Professors | Assistant Professors | Research Associate Professors | Research Assistant Professors | Instructors | Joint Faculty | Emeritus

PROFESSOR & CHAIR, BIOCHEMISTRY & MOLECULAR PHARMACOLOGY
Arthur F. and Helen P. Koskinas Professor of Biochemistry and Molecular Pharmacology

C. Robert Matthews, PhD - Investigation of structures and the dynamics of structural changes in biological molecules in solution, in particular, the mechanisms by which proteins fold to unique conformations; studies on the effects of single amino acid substitutions on the folding process; folding mechanisms of multi subunit peptides and proteins; protein engineering.

PROFESSOR & VICE-CHAIR, BIOCHEMISTRY & MOLECULAR PHARMACOLOGY

Reid Gilmore , PhD (Biochemistry & Molecular Pharmacology) – Molecular mechanism of protein translocation across the endoplasmic reticulum; analysis of asparagine-linked glycosylation in the endoplasmic reticulum.

PROFESSOR & DEAN OF THE GRADUATE SCHOOL OF BIOMEDICAL SCIENCES

Anthony Carruthers, PhD (Biochemistry & Molecular Pharmacology) - Mechanisms of glucose transport and glucose transport regulation.

PROFESSOR & ASSOCIATE DEAN OF BASIC AND BIOMEDICAL SCIENCES DIVISION & VICE-PROVOST OF ADMISSIONS

Kendall L. Knight, PhD (Biochemistry & Molecular Pharmacology)

ASSOCIATE DIRECTOR & GRADUATE DIRECTOR

William R. Kobertz, PhD (Biochemistry & Molecular Pharmacology) – Structure, function and modulation of ion channels.

ELEANOR EUSTIS FARRINGTON CHAIR OF CANCER RESEARCH, CO- DIRECTOR RNA AND NEURO THERAPEUTICS INSTITUTES (RTI, NTI)

Melissa J. Moore, PhD, Howard Hughes Medical Institute Professor (Biochemistry & Molecular Pharmacology, Co- Director RNA and Neuro Theapeutics Institutes) – Pre-mRNA splicing and its connections to intracellular mRNA localization, translation, and degradation. (RTI) This link goes to an external web site

PROFESSOR & DIRECTOR, PROGRAM IN BIOINFORMATICS & INTEGRATIVE BIOLOGY (BIB)

Zhiping Weng, PhD (Biochemistry & Molecular Pharmacology) - To explore and understand biological data through the application and development of computational tools. BIB This link goes to an external web site 

GRETCHEN STONE COOK PROFESSOR OF BIOMEDICAL SCIENCES & CO-DIRECTOR, RNA THERAPEUTICS INSTITUTE  (RTI)

Phillip D. Zamore, PhD, Howard Hughes Medical Institute Professor (Biochemistry & Molecular Pharmacology, Co-Director RNA Therapeutics Institute) - Control of mRNA stability and translation in development; molecular mechanisms of RNAi (post-transcriptional gene silencing). RTI This link goes to an external web site

VITOLD ARNETT PROFESSOR OF CELL BIOLOGY

Thoru Pederson, PhD (Biochemistry & Molecular Pharmacology) - Eukaryotic gene expression at the level of RNA processing; RNA protein interactions and RNA traffic. 

PROFESSOR & DIRECTOR, CENTER FOR AIDS RESEARCH (CFAR)

Celia A. Schiffer , PhD (Biochemistry & Molecular Pharmacology) - How conformational adaptability affects molecular recognition in drug resistant variants of HIV protease; tools are phage display, x-ray crystallography and molecular dynamics calculations. CFARThis link goes to an external web site

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PROFESSORS

Sumner H. Burstein, PhD (Biochemistry & Molecular Pharmacology) - Regulation of anandamide biosynthesis; signal transduction events involved in cannabinoid-induced arachidonate release.

Anthony Carruthers, PhD (Biochemistry & Molecular Pharmacology) - Mechanisms of glucose transport and glucose transport regulation.

Job Dekker, PhD (Program in Gene Function and Expression, Biochemistry & Molecular Pharmacology) - Spatial Organization of Genomes.

Reid Gilmore, PhD (Biochemistry & Molecular Pharmacology) – Molecular mechanism of protein translocation across the endoplasmic reticulum; analysis of asparagine-linked glycosylation in the endoplasmic reticulum.

Kendall L. Knight, PhD (Biochemistry & Molecular Pharmacology) – Genetic recombination and homologous recombinational DNA repair in human cells: Rad51-mediated DNA double-stranded break repair.

Martin G. Marinus, PhD (Biochemistry & Molecular Pharmacology) - Mechanism and specificity of DNA mismatch repair; drug resistance and DNA mismatch repair; function of methylated bases in nucleic acids.

C. Robert Matthews, PhD (Biochemistry & Molecular Pharmacology) - Investigation of structures and the dynamics of structural changes in biological molecules in solution, in particular, the mechanisms by which proteins fold to unique conformations; studies on the effects of single amino acid substitutions on the folding process; folding mechanisms of multi subunit peptides and proteins; protein engineering.

Dannel McCollum, PhD - (Biochemistry & Molecular Pharmacology) - Signaling pathways controlling cell growth and division

John R. McCullough
, PhD (Biochemistry & Molecular Pharmacology) - Pharmacology and pathophysiology of cardiovascular, pulmonary and urogenital systems; pharmacology of antihistamines, muscarinic antagonists and ion channel modulators; drug-induced cardiac arrhythmias; drug discovery and development; pharmacology education.

Melissa J. Moore, PhD, Howard Hughes Medical Institute Investigator (Biochemistry & Molecular Phamacology, Co-Director RNA and NeuroTherapeutics Institutes) - Pre-mRNA splicing and its connections to intracellular mRNA localization, translation, and degradation. (RTI) This link goes to an external web site

Thoru Pederson, PhD (Biochemistry & Molecular Pharmacology) - Eukaryotic gene expression at the level of RNA processing; RNA protein interactions and RNA traffic.

Alonzo H. Ross, PhD (Biochemistry & Molecular Pharmacology) - PTEN tumor suppressor and phosphataidylinositol phosphatase, CNS stem cells and neural tumors.

William E. Royer Jr. , PhD (Director, UMMS X-ray core facility; Biochemistry & Molecular Pharmacology) - X-ray crystallographic imaging of macromolecular structures; structural basis for intersubunit communication and macromolecular interactions. UMMS X-Ray Core Facility This link goes to an external web site

Celia A. Schiffer, PhD (Director Center for AIDS Research (CFAR), Biochemistry & Molecular Pharmacology) – How conformational adaptability affects molecular recognition in drug resistant variants of HIV protease; tools are phage display, x-ray crystallography and molecular dynamics calculations.CFARThis link goes to an external web site

Charles G. Sagerström, PhD (Biochemistry & Molecular Pharmacology) – Developmental neurobiology; molecular and genetic analysis of hindbrain formation

Paul Thompson, PhD - Professor
Techniques of chemical biology, biochemistry, and enzymology to develop inhibitors/drugs targeting disease associated enzymes as well as developing novel diagnostics for cancer.

Zhiping Weng, PhD (Director, Program in Bioinformatics and Integrative Biology; Biochemistry & Molecular Pharmacology) - To explore and understand biological data through the application and development of computational tools.  BIB This link goes to an external web site 

Zuoshang Xu, MD, PhD  (Biochemistry & Molecular Pharmacology) - Structure, transport and function of neuronal cytoskeleton; neurodegenerative disease.

Phillip D. Zamore, PhD, Howard Hughes Medical Institute Investigator  (Biochemistry & Molecular Pharmacology, Co-Director RNA Therapeutics Institute) - Control of mRNA stability and translation in development; molecular mechanisms of RNAi (post-transcriptional gene silencing). (RTI) This link goes to an external web site

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ASSOCIATE PROFESSORS

Dan Bolon, PhD (Biochemistry & Molecular Pharmacology) - The role of molecular chaperones in biology and disease.

William R. Kobertz, PhD (Biochemistry & Molecular Pharmacology) – Structure, function and modulation of ion channels.

Stephen Miller, PhD (Biochemistry & Molecular Pharmacology) - Illuminating biological processes with chemistry.

Mary Munson, PhD (Biochemistry & Molecular Pharmacology) – Regulation of vesicle targeting and fusion.

Peter Pryciak, PhD (Biochemistry & Molecular Pharmacology) - Signal transduction mechanisms and their regulatory interactions with the cell cycle.

Oliver J. Rando, PhD (Biochemistry & Molecular Pharmacology) - Role of chromatin structure in transcriptional control, and mechanism of inheritance of chromatin states; role of epigenetically inherited information in evolution, development, and disease.                                                                                                                                                                                                 

Nick Rhind, PhD (Biochemistry & Molecular Pharmacology) – Checkpoint regulation in the fission yeast cell cycle.

Sean Ryder, PhD (Biochemistry & Molecular Pharmacology) – RNA regulation in development and disease; regulatory networks, mechanism of specificity, and ribonucleoprotein complex assembly.

Scot Wolfe, PhD (Program in Gene Function and Expression, Biochemistry & Molecular Pharmacology) – Targeted gene regulation using novel, designed transcription factors.(Biochemistry & Molecular Pharmacology) – Developmental neurobiology; molecular and genetic analysis of hindbrain formation.

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ASSISTANT PROFESSORS

David Grünwald, PhD (Biochemistry & Molecular Pharmacology, RNA Therapeutics Institute) - Single molecule imaging of cell nuclear processes and nucleocytoplasmic transport in living cells.   

Gang Han, PhD (Biochemistry & Molecular Pharmacology) - Synthetic nanomaterials for siRNA delivery and biomolecule imaging. 

Brian Kelch, PhD (Biochemistry & Molecular Pharmacology) - Structure and mechanism of molecular machines that act on DNA.

Andrei Korostelev, PhD (Biochemistry & Molecular Pharmacology, RNA Therapeutics Institute) - Structure and function of ribosomes.

Francesca Massi , PhD (Biochemistry & Molecular Pharmacology) - Protein dynamics , function and stability using NMR and computer simulation. 

Konstantin Zeldovich, PhD (Program in Bioinformatics and Integrative Biology, Biochemistry & Molecular Pharmacology) - Molecular evolution and protein folding using computer simulations and theory.

 

RESEARCH PROFESSORS

Scott Shaffer, PhD (Director of UMMS Proteomic & Mass Spectrometry Facility; Biochemistry & Molecular Pharmacology) – Applications of mass spectrometry of proteomics, lipids, and small molecules. UMMS Proteomic & Mass Spectrometry Facility This link goes to an external web site   

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RESEARCH ASSOCIATE PROFESSORS

Osman Bilsel, PhD (Biochemistry & Molecular Pharmacology) - Use of time-resolved fluorescence, excitation energy transfer and rapid mixing techniques to obtain structural information on protein folding intermediates in the microsecond to seconds time regime.  See C.R. Matthews' Lab for more information.

John Leszyk, PhD (Associate Director of UMMS Proteomic & Mass Spectrometry Facility; Biochemistry & Molecular Pharmacology) - Applications of mass spectrometry to proteomics. UMMS Proteomic & Mass Spectrometry Facility This link goes to an external web site

Elisabet C. Mandon, PhD (Biochemistry & Molecular Pharmacology) - Molecular mechanisms that establish and maintain compartmentalization in living cells; protein sorting to the endoplasmic reticulum.  See  R. Gilmore's Lab for more information.

Simon Xi, PhD (Director,Bioinformatics Core Facility, Biochemistry & Molecular Pharmacology) - High through-put data generated from next-gen sequencing, microarray profiling to provide better understanding of disease mechanisms and biological processes. Bioinformatics CoreThis link goes to an external web site

Jill Zitzewitz, PhD (Biochemistry & Molecular Pharmacology) – Folding and assembly of multimeric proteins and peptides using stopped-flow circular dichroism and fluorescence spectroscopies. See  C.R. Matthews' Lab  for more information.

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RESEARCH ASSISTANT PROFESSORS

Akbar Ali, PhD (Biochemistry & Molecular Pharmacology) - Design, synthesis and structure-activity relationship studies of HIV-1 protease inhibitors active against multidrug-resistant (MDR) viruses. Synthesis and biological evaluation of small molecule inhibitors of PTEFb, and viral infectivity factor (Vif). See C. Schiffer's Lab for more information. 

Hong Cao, PhD (Biochemistry & Molecular Pharmacology) - The small moleule screening facility (SMSF) assists researchers in developing high-throughput (HT) screening assays, performs HT screens of chemical libraries to identify new small molecules that can be used to proble biological processes of interest.  Small Molecule Screening Facility  go to arrow.

Weijun Chen, PhD (Biochemistry & Molecular Pharmacology) - Structure and mechanism of the spliceosome using a combination of yeast genetics, biochemistry, mass spectroscopy, deep sequencing, electron microscopy and X-ray crystallography. See M. Moore's Lab for more information.

Nese Kurt Yilmaz, PhD (Biochemistry & Molecular Pharmacology) - Molecular recognition and drug resistance in viral proteases. See C.Schiffer lab for more information.

Brian Pierce, PhD - (Program in Bioinformatics and Integrative Biology, Biochemistry & Molecular Pharmacology) - Protein interaction modeling and design, structural bioinformatic, comutational structural immunology.  See Z. Wengs' Lab for more information.

Thom Vreven, PhD (Program in Bioinformatics and Integrative Biology, Biochemistry & Molecular Pharmacology) - Computational analysis and determination of protein-protein interactions. See Z. Weng's lab for more information.

Troy Whitfield, PhD (Program in Bioinformatics and Integrative Biology, Biochemistry & Molecular Pharmacology) - Regulatory genomics through the computational identification of transcription factor binding sites; molecular models of protein-DNA binding. See Z. Weng's lab for more information.

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INSTRUCTORS

Sagar Kathuria, PhD (Biochemistry & Molecular Phamacology) - Sequence determinats of the folding free-energy landscape of beta-alpha-repeat proteins. See C.R. Matthew's Lab for more information.

 

Inna Shcherbakova, PhD (Biochemistry & Molecular Pharmacology) - Studies of the spliceosome dynamics by single molecule fluorescence. See M. Moore's Lab for more information.

Victor Serebrov, PhD - (Biochemistry & Molecular Pharmacology) - Single molecule approaches to complex biological systems; DEAD-box proteins in translation initiation. See M. Moore's Lab for more information.

L. Safak Yilmaz, PhD - (Progam in Systems Biology, Biochemistry & Molecular Phamacology) - Genome-scale reconstruction of the metabolic network in Caenorhabditis elegans; structural aspects of drug resistance in Influenza. See C. Shiffer's lab for more information.

 

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JOINT FACULTY

Michael P. Czech, PhD (Director and Professor, Program in Molecular Medicine) - Transmembrane signaling mechanisms elicited by the insulin receptor tyrosine kinase related to membrane trafficking of glucose transporters.

Roger J. Davis, PhD, Howard Hughes Medical Institute Investigator (Professor, Program in Molecular Medicine) - Signal transduction by the epidermal growth factor receptor; mechanisms by which growth factors regulate cellular proliferation.

Mark Dershwitz, MD, PhD (Professor, Anesthesiology) – Clinical pharmacology of intravenous anesthetics and antiemetics.

Stephen Doxsey, PhD (Associate Professor, Program in Molecular Medicine) - Mitotic and meiotic spindle assembly with an emphasis on centrosome structure, functions, and regulation.

Michael R. Green, MD, PhD, Howard Hughes Medical Institute Investigator (Director and Professor, Program in Gene Function and Expression; Program in Molecular Medicine) - Eukaryotic gene function and expression.

Lawrence J. Hayward, MD, PhD (Associate Professor, Neurology) – Mechanisms of motor neuron degeneration, neuromuscular ion channel disorders. 

Omanand Koul, PhD (Research Associate Professor) - Eunice Kennedy Shriver Center for Mental Retardation

David G. Lambright, PhD (Professor, Program in Molecular Medicine) – Structural and molecular mechanisms of cell signaling and membrane trafficking.

Jeremy Luban, PhD(Professor, Program in Molecular Medicine) - HIV Replication, Pathogenesis, Immunity

Zdenka Matijasevic, PhD (Assistant Professor, Cell Biology) - DNA damage by antitumor and environmental alkylators; mechanisms of DNA repair; hypothermia and cell cycle.

Haley Melikian, PhD (Associate Professor, Psychiatry) – Cocaine and antidepressant-sensitive monoamine transporters

Craig L. Peterson, PhD (Professor, Program in Molecular Medicine) - Roles of the SWI/SNF complex and chromatin in regulation of eukaryotic gene expression.

Lawrence J. Stern, PhD (Professor, Pathology) - Molecular recognition in the immune system.

 

Alice Gardner, PhD (Adjunct Professor) - Massachusetts College of Pharmacy and Health Sciences

Tariq Rana, PhD (Adjunct Professor) - Burnham Institute

George E. Wright, PhD (Adjunct Professor) - GLSynthesis

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Emeritus and Distinguished Faculty

Quentin Gibson, PhD, Distinguished Professor
Neal C. Brown
, D.V.M., PhD Emeritus
Frank J. Chlapowski, PhD Emeritus
Jean-Pierre Flatt, PhD Emeritus
Thomas B. Miller Jr., PhD Emeritus
Carel Mulder, PhD Emeritus