Faculty

C. Robert Matthews, PhD - Professor & Chair, Arthur F. and Helen P. Koskinas Professor in Biochemistry
Solving the Protein Folding Problem.

Reid Gilmore, PhD - Professor and Vice-Chair
Molecular mechanism of secretory protein translocation.


Dan Bolon, PhD  - Associate Professor
Molecular mechanisms of adaptation in biology and disease.

Sumner H. Burstein, PhD - Professor
The Mechanism of Action of the Cannabinoids.

Anthony Carruthers, PhD - Professor and Dean of the Graduate School of Biomedical Sciences
Carrier-mediated transport.

Job Dekker, PhD - Professor, Program in Gene Function and Expression
Spatial Organization of Genomes. 

Reid Gilmore, PhD - Professor and Vice-Chair of Biochemistry & Molecular Pharmacology
Molecular mechanism of secretory protein translocation.

David Gr├╝nwald, PhD - Assistant Professor
Single molecule imaging of cell nuclear processes and nucleocytoplasmic transport in living cells.

Gang Han, PhD - Assistant Professor
Synthetic nanomaterials for therapeutic and imaging.

Brian Kelch PhD - Assistant Professor
Structure and mechanism of molecular machines that act on DNA.

Kendall L. Knight, PhD - Professor and Associate Dean of Basic and Biomedical Sciences Division & Vice-Provost of Admissions
Genetic recombination and homologous recombinational DNA repair in human cells: Rad51-mediated DNA double-strand break repair.

William R. Kobertz, PhD - Associate Professor and Graduate Director
Structure, function and modulation of ion channels.

Andrei Korostelev, PhD  - Assistant Professor, RNA Therapeutics Institute
Structure and function of the ribosome.

Martin G. Marinus, PhD  - Professor
DNA Repair and Recombination.

Francesca Massi, PhD - Assistant Professor
From protein dynamics to protein function and stability using NMR spectroscopy and computer simulation.

C. Robert Matthews, PhDProfessor & Chair of Biochemistry, Arthur F. and Helen P. Koskinas Professor
Solving the Protein Folding Problem.

Dannel McCollum, PhD Professor
Signaling pathways controlling cell growth and division

John R. McCullough, PhD - Professor
Pharmacology and pathophysiology of cardiovascular, pulmonary and urogenital systems; pharmacology of antihistamines; drug-induced cardiac arrhythmias; drug discovery and development; pharmacology education.

Stephen Miller, PhD  - Associate Professor
Illuminating biological processes with chemistry.

Melissa J. Moore, PhD, Howard Hughes Medical Institute Investigator - Professor, Eleanor Eustis Chair of Cancer Research and Co-Director of RNA and NTI Therapeutics Institutes. RTIThis link goes to an external web site
Eukaryotic RNA Processing and Metabolism. 

Mary Munson, PhD  - Associate Professor
Regulation of vesicle targeting and fusion.

Thoru Pederson, PhD  - Professor and Vitold Arnett Professor of Cell Biology
RNA traffic in eukaryotic cells, RNA processing, RNA-protein interactions, siRNA.

Peter Pryciak, PhD - Associate Professor
Signal transduction mechanisms and their regulatory interactions with the cell cycle.

Oliver J. Rando, PhD - Associate Professor
Genomic approaches to chromatin structure and function, and to epigenetic inheritance.

Nick Rhind, PhD  - Associate Professor
Checkpoint Regulation of the Fission Yeast Cell Cycle.

Alonzo H. Ross, PhD  - Professor
PTEN phosphatase and tumor suppressor, CNS Stem Cells and neural tumors.

William E. Royer Jr. , PhD - Professor and Director of UMMS X-ray Core Facility
Structural basis for assembly and functional regulation in macromolecular complexes. UMMS X-Ray Core FacilityThis link goes to an external web site

Sean Ryder, PhD - Associate Professor
Post-transcriptional regulation of maternal mRNAs in early development.

Charles G. Sagerstr├Âm, PhD - Professor
Gene expression in embryogenesis.

Celia A. Schiffer, PhD - Professor and Director of Center for AIDS Research
Structural basis for molecular recognition in HIV Protease.

Paul Thompson, PhD - Professor
Techniques of chemical biology, biochemistry, and enzymology to develop inhibitors/drugs targeting disease associated enzymes as well as developing novel diagnostics for cancer.

Zhiping Weng, PhD - Professor and Director of Program in Bioinformatics and Integrative Biology
Bioinformatics and Computational Genomics. BIB This link goes to an external web site 

Scot Wolfe, PhD - Associate Professor, Program in Gene Function and Expression
Creating artifical DNA-binding domains for targeted gene regulation and gene modification.

Zuoshang Xu, MD, PhD  - Professor
Mechanism and therapy of neurodegenerative diseases.

Phillip D. Zamore, PhD, Howard Hughes Medical Institute Investigator - Professor, Gretchen Stone Cook Professor of Biomedical Sciences, and Co-Director of RNA Therapeutics Institute. RTI This link goes to an external web site
Dissecting the RNAi and miRNA pathways. Zamore Lab This link goes to an external web site

Konstantin Zeldovich, PhD - Assistant Professor, Program in Bioinformatics and Integrative Biology
Physics-based models of molecular evolution


Research Faculty

Akbar Ali, PhD - Research Associate Professor
Design, synthesis and structure-activity relationship studies of HIV-1 protease inhibitors active against multidrug-resistant (MDR) viruses. Synthesis and biological evaluation of small molecule inhibitors of PTEFb, and viral infectivity factor (Vif). See C. Schiffer's Lab for more information. 

Osman Bilsel, PhD - Research Associate Professor
Use of time-resolved fluorescence, excitation energy transfer and rapid mixing techniques to obtain structural information on protein folding intermediates in the microsecond to seconds time regime.  See C.R. Matthews' Lab for more information.

Hong Cao, PhD - Research Assistant Professor
The small moleule screening facility (SMSF) assists researchers in developing high-throughput (HT) screening assays, performs HT screens of chemical libraries to identify new small molecules that can be used to proble biological processes of interest.  Small Molecule Screening Facility  go to arrow

Weijun Chen, PhD - Research Assistant Professor
Structure and mechanism of the spliceosome using a combination of yeast genetics, biochemistry, mass spectroscopy, deep sequencing, electron microscopy and X-ray crystallography. See M. Moore's lab for more information.

Sagar Kathuria, PhD - Instructor
Sequence determinants of the folding free-energy landscape of the beta-alpha-repeat proteins. See C.R. Matthews' Lab for more information.

Nese Kurt Yilmaz, PhD - Research Assistant Professor
Molecular recognition and drug resistance in viral proteases. See C.Schiffer lab for more information.

John Leszyk, PhD - Research Associate Professor and Associate Director of UMMS Proteomic & Mass Spectrometry Facility
Applications of mass spectrometry to proteomics.  UMMS Proteomic & Mass Spectromety FacilityThis link goes to an external web site 

Elisabet C. Mandon, PhD - Research Associate Professor
Molecular mechanisms that establish and maintain compartmentalization in living cells; protein sorting to the endoplasmic reticulum.  See  R. Gilmore's Lab for more information.

Brian Pierce, PhD - Research Assistant Professor, Program in Bioinformatics and Integrative Biology
Protein interaction modeling and design, structural bioinformatics, computational structural immunology.  See Z. Weng's Lab for more information.

Victor Serebrov, PhD - Instructor
Single molecule approaches to complex biological systems; DEAD-box proteins in translation initiation. See M. Moore's Lab for more information.

Scott Shaffer, PhD - Research Professor and Director of UMMS Proteomic & Mass Spectrometry Facility
Applications of mass spectrometry to protemics, lipids, and small molecules. UMMS Proteomic & Mass Spectrometry Facility This link goes to an external web site

Inna Shcherbakova, PhD - Instructor
Studies of the spliceosome dynamics by single molecule fluorescence. See M. Moore's Lab for more information.

Thom Vreven, PhD - Research Assistant Professor, Program in Bioinformatics and Integrative Biology
Computational analysis and determination of protein-protein interactions. See Z. Weng's lab for more information.

Troy Whitfield, PhD - Research Assitant Professor, Cell Biology
Computational analysis and determination of protein-protein interactions.

L. Safak Yilmaz, PhD - Instructor
Genome-scale reconstruction of the metabolic network in Caenorhabditis elegans; structural aspects of drug resistance in Influenza. See C. Shiffer's lab for more information.

Jill Zitzewitz, PhD - Research Associate Professor
Folding and assembly of multimeric proteins and peptides using stopped-flow circular dichroism and fluorescence spectroscopies. See  C.R. Matthews' Lab  for more information.


Joint Faculty

Daryl A. Bosco, PhD - Assistant Professor, Neurology
Elucidating the factors involved in sporadic ALS

Michael P. Czech, PhD - Professor and Director, Program in Molecular Medicine
RNAi-based therapeutic strategies for inflammatory and metabolic diseases.

 

 

 

 

 

 

 

 

 

 

 

 

Roger J. Davis, PhD, Howard Hughes Medical Institute Investigator - Professor, Program in Molecular Medicine
Mechanisms by which growth factors regulate cellular proliferation.

Mark Dershwitz, MD, PhD - Professor, Anesthesiology
Clinical pharmacology of intravenous anesthetics and antiemetics.

Stephen Doxsey, PhD - Associate Professor, Program in Molecular Medicine
Regulation of Mitotic Spindle Assembly

Michael R. Green, MD, PhD, Howard Hughes Medical Institute InvestigatorProfessor and Director, Program in Gene Function and Expression
Eukaryotic Gene Regulation and Cancer Molecular Biology.

Lawrence J. Hayward, MD, PhD - Associate Professor, Neurology
Motor Neuron Disease Mechanisms.

Omanand Koul, PhD - Research Associate Professor, Eunice Kennedy Shriver Center for Mental Retardation

David G. Lambright, PhD - Professor, Program in Molecular Medicine
Structural and molecular mechanisms of cell signaling and membrane trafficking.

Jeremy Luban, PhD - Professor, Program in Molecular Medicine
HIV Replication, Pathogenesis, and Immunity.

Zdenka Matijasevic, PhD - Assistant Professor, Cell Biology
Role of MdmX in Cell Transformation and Tumorigenesis.

Haley Melikian, PhD  - Associate Professor, Psychiatry
Cocaine and antidepressant-sensitive monoamine transporters.

Craig L. Peterson, PhD - Professor, Program in Molecular Medicine
How chromosome structure influences nuclear processes.

Lawrence J. Stern, PhD - Professor, Pathology
Molecular recognition in the immune system.

Alice Gardner, PhD - Adjunct Professor, Massachusetts College of Pharmacy and Health Sciences

Tariq Rana, PhD -Adjunct Professor, Burnham Institute 

George E. Wright, PhD - GLSynthesis


Emeritus and Distinguished Faculty

Neal C. Brown, D.V.M., PhD Emeritus
Frank J. Chlapowski, PhD Emeritus
Jean-Pierre Flatt, PhD Emeritus
Quentin Gibson, PhD, Distinguished Professor
Thomas B. Miller Jr., PhD Emeritus
Carel Mulder, PhD Emeritus