BMP Research

  • Massi

    Proteins are flexible molecules that undergo conformational changes to perform biological functions. We study the relationship between structure, stability, and dynamics of proteins using NMR spectroscopy and computational methods. (Massi Lab)

  • Bolon

    EMPIRIC approach to analyze the fitness effects of mutations in parallel reveals fundamental evolution constaints. Background: heat map of a fitness landscape for a region of the yeast Hsp90 gene. (Bolon Lab)

  • Burstein

    Anandamide from the Sanskit ananda, which means "bliss" is an endogenous cannabinoid found in animal and human organs. (Burstein Lab)

  • Knight

    DNA damage induces networked signaling and repair activities in human cells. (Top) Phosphorylation of histone H2AX revealed by 4Pi microscopy and (Bottom) the recruitment of Rad51 into the nucleus and to the sites of chromatin breaks. (Knight Lab)

  • Kobertz

    Heteromeric KCNQ1/KCNE1/KCNE4 K+ currents (aqua) visualized using a chemically-derivatized scorpion toxin (red) that specifically labels ion channel subunits in living cells. (Kobertz Lab)

  • Marinus

    Formation of F-actin Hela cells by Escherichia coli. A Hela cell infected with a dam mutant E. coli is shown stained with DAPI (left), filamentous actin stain (middel panel) and the merged image (right). (Marinus Lab)

  • Exocyst system

    The exoscyst complex localizes to sites of polarized graoth and secretion, where it functions to regulate trafficking and membrane fucsion of secretory vesicles with the plams membrane. Structure of Sec6p, a subunit of the exocyst complex. (Munson lab)

  • Upconverting nanoparticles absorb multiple photons in the near infrared and emit shorter wavelengths

    Upconverting nanoparticles absorb multiple photons in the near infrared and emit shorter wavelengths. They are extrememly photostable, non-blinking and have deep penetration depths, which is ideal for single molecule and animal imaging. (Han lab)

  • Crystal structure of the 70S ribosome bound with release factor RF1

    Crystal structure of the 70S ribosome bound with release factor RF1 (a) provides insights into the mechanism of peptidyl-tRNA hydrolusis (b) during translation termination. Kinetic studies (c) are used to test the structure-based hyptheses. (Korostelev lab)

  • Light emission from luciferase is widely used as a biological reporter

    Light emission from firefly luciferase is widely used as a biological reporter, but is fundamentally limited by D-luciferin. Synthetic aminoluciferins exhibit red light emission, higher cell permeability, and increased affinity for luciferase. (Miller lab)

  • Genome-widr approaches to chromatin structure

    Genome-widr approaches to chromatin structure. Background: clustered microarray data on histone modifications. Foreground cartoon: model of histome dynamics,  where circles represent nucleosomes and red boxes represent promoters. (Rando lab)

  • Individual DNA molecules stretched on a glass surface

    Individual DNA molecules stretched on a glass surface and visualized with flourescent probes; the green is DNA and the red marks replication bubbles. This assay is used to study the kinetics of DNA replication. (Rhind lab)

  • Combining a drug that inhibits Notch signaling (DPT) with chemotherapy drug temozolomide( TMZ)

    Combining a drug that inhibits Notch signaling (DPT) with chemotherapy drug temozolomide( TMZ) prevented tumor formation by deadly glioma tumors in mice, as well as cultured neurospheres, which are non adherent cell aggregates. (Ross lab)

  • Interferon regulatory factors (IRFs)

    Interferon regulatory factors (IRFs) play key roles in host defense mechanisms including innate immunity and tumor suppression. IRF-5, whose activated dimeric struture os shown here, is a potential drug target for autoimmune diseases. (Royer lab)

  • RNA-binding proteins regulate several aspects of Caenorhabditis elegans germline development and early patterning events

    RNA-binding proteins regulate several aspects of Caenorhabditis elegans germline development and early patterning events. Our lab studies how the maternal "load" is established in the germline and how it is decoded after fertilization. (Ryder lab)