Victor Ambros, PhD - (Program in Molecular Medicine) We study gene regulatory mechanisms controlling the timing of animal development, using the C. elegans model system. Developmental timing regulators in C. elegans include microRNAs that control the stage-specific expression of key transcription factors. We aim to understand the molecular mechanisms of post-transcriptional gene regulation by microRNAs, and how microRNAs function in regulatory networks affecting development and disease.
Eric H. Baehrecke, PhD - (Department of Cancer Biology) Cell death and autophagy.
Dan Bolon, PhD - (Department of Biochemistry & Molecular Pharmacology) The role of molecular chaperones in biology and disease.
Michael Brodsky, PhD - (Program in Gene Function and Expression) Regulation of Drosophila p53 and DNA Damage-Induced Apoptosis.
Robert H. Brown, MD, PhD - (Chair, Department of Neurology) The lab has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis. Knowledge of theses disease genes has facilitated the creation of mouse and cell-based models of these disorders. In turn, these resources have allowed study of therapeutic strategies using conventional small molecule approaches and new modalities such as inhibitory RNAi.
Daniel Caffrey, PhD - (Department of Medicine) Molecular Evolution, Structural Bioinformatics and Systems Biology of the Immune Response.
Anthony Carruthers, PhD - (Department of Biochemistry and Molecular Pharmacology and Dean of the Graducate School of Biomedical Sciences) Carrier-mediated transport.
Craig Ceol, PhD - (Program in Molecular Medicine) Our laboratory is interested in the genetic and molecular mechanisms underlying tumor initiation and maintenance. We focus primarily on melanoma, using genetically-engineered zebrafish models and mammalian cultured cells to identify unique features of cancer cells that can potentially be used for diagnostic, prognostic or therapeutic benefit.
Michael Czech, PhD - (Chair, Program in Molecular Medicine) Our laboratory group is dedicated to the discovery of molecular mechanisms whereby insulin signaling regulates energy homeostasis. This quest includes RNAi screens, digital imaging and TIRF microscopy, phenotyping mice with gene knockouts and analysis of human adipose tissues. We hope to translate our findings to the prevention and treatment of type 2 diabetes.
Job Dekker, PhD - (Co-Director, Program in Systems Biology and Professor in Program in Gene Function and Expression and Department of Biochemistry & Molecular Pharmacology) Spatial Organization of Genomes.
Thomas Fazzio, PhD - (Program in Gene Function and Expression) Chromatin Regulation in Stem Cells.
Patrick Flaherty, PhD - (Worcester Polytechnic Institute (WPI) - Biomedical Engineering also affiliated with Bioinformatics and Computational Biology at WPI) The goal of my research is to develop statistical methods for very large data sets to understand and quantify the contribution of genetic factors to improve the diagnosis and treatment of cancer and other genetic diseases.
Michael Green, MD, PhD - (Director, Program in Gene Function and Expression, Program in Molecular Medicine) My lab is interested in the mechanisms that regulate gene expression in eukaryotes, and the role of gene expression in various human disease states. A major emphasis is the use of transcription-based approaches and functional screens to identify new genes and regulatory pathways involved in cancer.
Paul Kaufman, PhD - (Program in Gene Function and Expression) Assembly and Function of Eukaryotic Chromosomes.
Thomas Houston, MD., PhD - (Quantitative Health Sciences and Division Chief of Health Informatics and Implementation Sciences) My research focus combines health informatics, communication, and behavioral science.
Catarina Kiefe, MD., PhD - (Chair, Quantitative Health Sciences) I combine the rigor of mathematics with the needs of clinical medicine.
Allan Jacobson, PhD - (Chair, Microbiology and Physiological Systems) Cytoplasmic Aspects of the Post-transcriptional Regulation of Gene Expression.
Nathan Lawson, PhD - (Program in Gene Function and Expression) Determining Signals Responsible for Blood Vessel Development using Zebrafish.
Katherine Luzuriaga, MD - (Program in Molecular Medicine and Department of Pediatrics-Pediatric Immunology and Infectious Diseases) Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV).
Francesca Massi, PhD - (Department of Biochemistry & Molecular Pharmacology) Protein dynamics , function and stability using NMR and computer simulation.
C. Robert Matthews, PhD - (Chair, Department of Biochemistry & Molecular Pharmacology) Investigation of structures and the dynamics of structural changes in biological molecules in solution, in particular, the mechanisms by which proteins fold to unique conformations; studies on the effects of single amino acid substitutions on the folding process; folding mechanisms of multi subunit peptides and proteins; protein engineering.
Craig Mello, PhD - (Program in Molecular Medicine) Our lab uses the nematode worm C. elegans as a model organism to investigate how embryonic cells differentiate and communicate during development. In addition, we are investigating the mechanism of RNA interference, a form of sequence-specific gene silencing triggered by double-stranded RNA.
Arthur M. Mercurio, PhD - (Interim Chair, Department of Cancer Biology) Mechanisms of carcinoma progression.
Eric Mick, ScD - (Quantitative Health and Sciences) My research is focused on identifying genetic susceptibility to disruptive behavior and mood disorders in children, adolescents and adults.
Melissa Moore, PhD - (Department of Biochemistry & Molecular Pharmacology) Pre-mRNA splicing and its connections to intracellular mRNA localization, translation, and degradation.
Ollie Rando, MD, PhD - (Department of Biochemistry & Molecular Pharmacology) Role of chromatin structure in transcriptional control, and mechanism of inheritance of chromatin states; role of epigenetically inherited information in evolution, development, and disease.
Nick Rhind, PhD - (Department of Biochemistry & Molecular Pharmacology) Checkpoint regulation in the fission yeast cell cycle.
Evgeny Rogaev, PhD - (The Brudnick Neuropsychiatric Research Institute (BNRI), Department of Psychiatry) Our research is focused on the identification of genes and cellular proteins that play a critical role in normal and pathological aspects of human behavior.
Sean Ryder, PhD - (Department of Biochemistry & Molecular Pharmacology) RNA regulation in development and disease; regulatory networks, mechanism of specificity, and ribonucleoprotein complex assembly.
Christopher Sassetti, PhD - (Microbiology and Physiological Systems) Pathogenesis of tuberculosis.
Celia Schiffer, PhD - (Department of Biochemistry & Molecular Pharmacology) How conformational adaptability affects molecular recognition in drug resistant variants of HIV protease; tools are phage display, x-ray crystallography and molecular dynamics calculations.
Scott Shaffer, PhD - (Director, UMMS Proteomic & Mass Spectrometry Faciltity; Department of Biochemistry & Molecular Pharmacology) Applications of mass spectrometry to protemics, lipids, and small molecules.
Neal S. Silverman, PhD - (Department of Medicine, Division of Infectious Diseases and Immunology) The main goal of our lab is to decipher the molecular mechanisms responsible for transmitting a signal from the site of infection to the nucleus of an immune responsive cell.
William Theurkauf, PhD - (Program in Molecular Medicine) Work in the lab addresses RNA localization and embryonic patterning, the response of mitotic cells to DNA damage, and small RNA function in germline development. Studies combine high resolution imaging, genetic, and molecular approaches in Drosophila and mammalian cultured cell systems.
Marian Walhout, PhD - (Co-Director, Program in Systems Biology and Professor in Program in Gene Function and Expression and Program in Molecular Medicine) We aim to understand how regulatory networks control animal development, function, and homeostasis; and how dysfunctional networks affect or cause diseases like diabetes, obesity and cancer. We use a combination of experimental and computational systems biology methods to map, characterize and manipulate regulatory networks, most notably in the nematode C. elegans.
Troy Whitfield, PhD - (Cell Biology) Regulatory genomics through the computational identification of transcription factor binding sites; molecular models of protein-DNA binding.
Scot Wolfe, PhD - (Program in Gene Function and Expression, Department of Biochemistry & Molecular Phamacology) – Targeted gene regulation using novel, designed transcription factors.
Hong Yu, PhD - (Quantitative Health and Sciences - Informatics and Implementation Science)
Phillip D. Zamore, PhD - (Department of Biochemistry & Molecular Pharmacology) Control of mRNA stability and translation in development; molecular mechanisms of RNAi (post-transcriptional gene silencing).
Julie Zhu, PhD - (Program in Gene Function and Expression and Program in Molecular Medicine) Computational Biology and Bioinformatics.
Simon Xi, PhD - (Pfizer Group) Research interests include analyzing high through-put data generated from next-gen sequencing, microarray profiling to provide better understanding of disease mechanisms and biological processes.