Advanced Topics in Cell Biology

Mammalian Development and Stem Cells

The potential of stem cells in therapeutic applications has ignited a fiercely competitive field of research aimed at the isolation, maintenance and differentiation of stem cells into specific pathways of differentiation. The use of stem cells in clinical application, however, requires an understanding of the molecular and cellular and epigenetic events that transform pluripotent cells into differentiated ones. Mammalian embryogenesis can be conceived as a sequence of developmental decisions that result in progressive restriction in cell potency. In this course we will use the cellular and molecular mechanisms of mammalian development as a framework for understanding the origin and differentiation of multiple pluripotent cells and their role in stem cell research and human disease.
Catalog number: BBS737
Course Coordinator: Jaime Rivera
Semester Offered: Fall
Last Taught: Fall 2012

Cell Signal Transduction

Proper intracellular signaling is critical to cell growth and differentiation, and dysregulation of signal transduction underlies a wide variety of human disorders. This course will examine various signal transduction pathways utilized by eukaryotes. A different pathway will be discussed each week, with special emphasis on the biological role(s) of the pathway in cell growth and function. Research papers highlighting one or more aspects of the signal pathway will be assigned for student presentation.
Catalog number: BBS722
Course Coordinator: Stephen Jones
Semester Offered: Spring
Last Taught: Spring 2013

Disruption of Cellular Architecture and Human Disease

This course explores the relationships between basic cellular structures, components and processes, from the membrane through the cytoplasm and into the nucleus, and human diseases. Topics will be chosen from the recent literature to illustrate molecular and cellular aspects of cellular architecture and how defects contribute to disease. The format includes student presentations and faculty-student discussions of selected research papers. Topically, this new course represents a fusion of the existing Nuclear Structure and Disease (BBS734) and Cytoskeleton and Disease (BBS733) courses that are offered by the Cell Biology program.
Catalog number: BBS788
Course Coordinator: Hong Zhang
Semester Offered: Spring
Last Taught: Spring 2014

Nuclear Structure and Function in Disease

This course encompasses the relationship of nuclear and chromatin structure to gene function and regulation. Topics will be chosen from the recent research literature to illustrate molecular and cellular aspects of nuclear organization and regulation and how defects contribute to human disease. The format includes student presentations and faculty-student discussions of selected research papers. 
Catalog number: BBS734
Course Coordinator: Anthony Imbalzano
Semester Offered: Spring, Even Years
Last Taught: Fall 2011

Cytoskeleton and Disease

This course focuses on functions of actin- and microtubule-based cytoskeleton systems in the context of human disease, organized as a series of seminars with presentations by students and faculty. Discussions will include how molecular information contributes to diagnosis and treatment of disease and how clinical phenotypes elucidate protein functioning in whole organisms. 
Catalog number: BBS733
Course Coordinator: Elizabeth Luna
Semester Offered: Fall, Odd Years
Last Taught: Has not been taught within past 2 years

Image Works - Principles of Light and Electron Microscopy

This course covers principles and applications of microscopy in biomedical research for graduate students at all levels. Demonstrations and laboratory exercises will be incorporated into some blocks of instruction. This course is designed to teach the biologist how microscopes work and how to optimize image quality. 
Catalog number: BBS732
Course Coordinator: Michael Sanderson
Semester Offered: Spring, Odd Years
Last Taught: Spring 2013

Cancer Biology

This course provides students with a rigorous and comprehensive understanding of the mechanisms that underlie the genesis and progression of human cancers. It builds on the basic science knowledge acquired in the core curriculum and the appreciation of cancer as a disease obtained from the Pathology and Cancer Medicine courses. The salient topics covered include stem cells, oncogenes and tumor suppressor genes, tumor-host interactions, invasion, metastasis and angiogenesis. A major theme of the course is to integrate the biology of cancer with the clinical behavior of tumors. Faculty from the Department of Cancer Biology and other basic science departments participate in the teaching of this course.
Catalog number: BBS725
Course Coordinator: Arthur Mercurio
Semester Offered: Fall
Last Taught: Fall 2013

Human Genetics

This course focuses strictly on human and clinically relevant genetics with emphasis on the basic underlying scientific mechanisms and concepts. Chromosomal, single gene, multifactorial and non-mendelian inheritance, as well as cancer genetics and human genomics will be covered. Problem solving will involve clinical, molecular and statistical data. A framework for understanding a fast-growing and highly technical field, and an appreciation of how current research impacts diagnostic, prenatal and pre-symptomatic testing, genetic screening and therapy, will be provided. This is a Medical School course. Approval of instructor required for registration. 
Catalog number: BBS736
Course Coordinator: Beverly Hay
Semester Offered: Fall
Last Taught: Fall 2012

Eukaryotic Gene Regulation

This course encompasses current research in important areas of eukaryotic gene regulation. The goals are two-fold: to improve skills in reading, presenting, discussing and critically analyzing research articles, and to obtain an up-to-date understanding of some key topics in eukaryotic gene regulation. Format involves student presentations and faculty-student discussions. 
Catalog number: BBS738
Course Coordinator: Michael Green
Semester Offered: Spring, Even Years
Last Taught: Has not been taught within past 2 years

Developmental Biology

This course concentrates on salient papers in areas of developmental biology that are presently under intensive investigation. Probable topics to be covered include maternal inheritance, establishment of the body plan, cell-cell signaling, neurogenesis, limb development and left-right asymmetries. The organisms that are used most extensively for these investigations, including Drosophila, zebrafish, Xenopus, C. elegans and the mouse, will be emphasized. 
Catalog number: BBS739
Course Coordinator: Michael Brodsky
Semester Offered: Fall
Last Taught: Has not been taught within past 2 years

 

 

Tutorials, Seminars, and Journal Clubs

Tutorial in Cell Biology

Tutorial arranged with individual faculty. 
Catalog number: BBS842
Course Coordinator: Anthony Imbalzano
Semester Offered: Fall, Spring and Summer
Last Taught: Spring 2014

Seminar in Cell Biology

Seminar series in Developmental, Cell and Molecular Biology.
Catalog number: BBS811
Course Coordinator: Jane Lian
Semester Offered: Fall and Spring
Last Taught: Fall 2011