Research at UMass Medical School

The Office of the Vice Provost of Research promotes, advances, and supports the faculty of the UMass Medical School in pursuit of their research goals. Research is a priority within the University and within the regional, state and national landscape. We are committed to a culture of excellence in research practice and regulatory compliance.

The scientific climate at the UMass Medical School is conducive to the conduct of interdisciplinary research. The extraordinary resourcefulness of the faculty and their commitment to excellence have contributed significantly to the success of our research initiatives.

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Dr. John Sullivan, MD
Vice Provost for Research

2009 Publications

• Berg Leslie J Strength of T cell receptor signaling strikes again Immunity. 2009 Oct 16;31(4):529-31.
• Hearn A, York IA, Rock KL. The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum J Immunol. 2009 Oct 14.
• Hammell CM, Karp X, Ambros V. A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans Proc Natl Acad Sci U S A. 2009 Oct 14.
• Zaidi SK, Dowdy CR, van Wijnen AJ, Lian JB, Raza A, Stein JL, Croce CM, Stein GS. Altered Runx1 Subnuclear Targeting Enhances Myeloid Cell Proliferation and Blocks Differentiation by Activating a miR-24/MKP-7/MAPK Network Cancer Res. 2009 Oct 13.
• Siekmann Arndt F, Standley Clive, Fogarty Kevin E, Wolfe Scot A, Lawson Nathan D Chemokine signaling guides regional patterning of the first embryonic artery Genes Dev. 2009 Oct 1;23(19):2272-7.
• Cerny Jan, Trneny Marek, Slavickova Alena, Pytlik Robert, Salkova Jana, Valkova Veronika, Liu Qin, Houghton JeanMarie, Klener Pavel Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders Hematology. 2009 Aug;14(4):187-97.
• Fuentes-Medel Yuly, Logan Mary A, Ashley James, Ataman Bulent, Budnik Vivian, Freeman Marc R Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris PLoS Biol. 2009 Aug;7(8):e1000184. Epub 2009 Aug 25.
• Grove Christian A, De Masi Federico, Barrasa M Inmaculada, Newburger Daniel E, Alkema Mark J, Bulyk Martha L, Walhout Albertha J M A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors Cell. 2009 Jul 23;138(2):314-27.
• Murphy MM, Simons JP, Hill JS, McDade TP, Chau Ng S, Whalen GF, Shah SA, Harrison LH Jr, Tseng JF. Pancreatic resection: a key component to reducing racial disparities in pancreatic adenocarcinoma Cancer. 2009 Jun 9.
• Mehta Nishaki, Trzmielina Sonia, Nonyane Bareng A S, Eliot Melissa N, Lin Rongheng, Foulkes Andrea S, McNeal Kristina, Ammann Arthur, Eulalievyolo Vindu, Sullivan John L, Luzuriaga Katherine, Somasundaran Mohan Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR PLoS One. 2009 Jun 5;4(6):e5819.
• Santra Manas K, Wajapeyee Narendra, Green Michael R F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage Nature. 2009 Jun 4;459(7247):722-5. Epub 2009 May 3.
• Stoicov C T-bet Knockout Prevents Helicobacter felis-Induced Gastric Cancer J Immunol. 2009 Jun 17.
• Liu Ping, Woda Marcia, Ennis Francis A, Libraty Daniel H Dengue Virus Infection Differentially Regulates Endothelial Barrier Function over Time through Type I Interferon Effects J Infect Dis. 2009 Jul 15;200(2):191-201.
• Park B Recent Trends in Clinical Outcomes and Resource Utilization for Pulmonary Embolism in the United States: Findings From the Nationwide Inpatient Sample Chest. 2009 Jun 12.
• Li H, Fan X, Stoicov C, Liu JH, Zubair S, Tsai E, Ste Marie R, Wang TC, Lyle S, Kurt-Jones E, Houghton J. Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver Gastroenterology. 2009 Jun 11.
• Pino Steven C, O'Sullivan-Murphy Bryan, Lidstone Erich A, Yang Chaoxing, Lipson Kathryn L, Jurczyk Agata, diIorio Philip, Brehm Michael A, Mordes John P, Greiner Dale L, Rossini Aldo A, Bortell Rita CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells PLoS One. 2009;4(5):e5468. Epub 2009 May 8.
• Aouadi Myriam, Tesz Gregory J, Nicoloro Sarah M, Wang Mengxi, Chouinard My, Soto Ernesto, Ostroff Gary R, Czech Michael P Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation Nature. 2009 Apr 30;458(7242):1180-4.
• Miller David M, Thornley Thomas B, Pearson Todd, Kruger Annie J, Yamazaki Masahiro, Shultz Leonard D, Welsh Raymond M, Brehm Michael A, Rossini Aldo A, Greiner Dale L TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade J Immunol. 2009 May 1;182(9):5547-59.
• Carlson D, McKeen E, Mitchell M, Torres B, Parad R, Comeau AM, O'Sullivan BP. Oropharyngeal flora in healthy infants: Observations and implications for cystic fibrosis care Pediatr Pulmonol. 2009 Apr 9;44(5):497-502.
• Goldberg Robert J, Spencer Frederick A, Gore Joel M, Lessard Darleen, Yarzebski Jorge Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective Circulation. 2009 Mar 10;119(9):1211-9. Epub 2009 Feb 23.
• Godoy Luiz C, Munoz-Pinedo Cristina, Castro Laura, Cardaci Simone, Schonhoff Christopher M, King Michael, Tortora Veronica, Marin Monica, Miao Qian, Jiang Jian Fei, Kapralov Alexandr, Jemmerson Ronald, Silkstone Gary G, Patel Jinal N, Evans James E, Wilson Michael T, Green Douglas R, Kagan Valerian E, Radi Rafael, Mannick Joan B Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2653-8. Epub 2009 Feb 5.
• Mathurin Keisha S, Martens Gregory W, Kornfeld Hardy, Welsh Raymond M CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses J Virol. 2009 Apr;83(8):3528-39. Epub 2009 Feb 4.
• Doubeni Chyke A, Li Wenjun, Fouayzi Hassan, DiFranza Joseph R Perceived accessibility of cigarettes among youth: a prospective cohort study Am J Prev Med. 2009 Mar;36(3):239-42. Epub 2009 Jan 21.
• Crowley Jessica L, Smith Tara C, Fang Zhiyou, Takizawa Norio, Luna Elizabeth J Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency Mol Biol Cell. 2009 Feb;20(3):948-62. Epub 2008 Dec 24.
• Songer Jennifer A, Munson Mary Sec6p anchors the assembled exocyst complex at sites of secretion Mol Biol Cell. 2009 Feb;20(3):973-82. Epub 2008 Dec 10.
• Willis Nicholas, Rhind Nicholas Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint Mol Biol Cell. 2009 Feb;20(3):819-33. Epub 2008 Nov 26.
• Zhang Ying, Hassan Mohammad Q, Xie Rong-Lin, Hawse John R, Spelsberg Thomas C, Montecino Martin, Stein Janet L, Lian Jane B, van Wijnen Andre J, Stein Gary S Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats) J Biol Chem. 2009 Jan 30;284(5):3125-35. Epub 2008 Nov 18.
• Akbarian Schahram, Huang Hsien-Sung Epigenetic regulation in human brain-focus on histone lysine methylation Biol Psychiatry. 2009 Feb 1;65(3):198-203. Epub 2008 Sep 24.
• Boudanova Ekaterina, Navaroli Deanna M, Stevens Zachary, Melikian Haley E Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization Mol Cell Neurosci. 2008 Oct;39(2):211-7. Epub 2008 Jun 25.
• Li Z, Hassan MQ, Jafferji M, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation J Biol Chem. 2009 Apr 2.
• Kenzel S, Santos-Sierra S, Deshmukh SD, Moeller I, Ergin B, Fitzgerald KA, Lien E, Akira S, Golenbock DT, Henneke P. ROLE OF P38 AND EGR-1 IN THE MACROPHAGE RESPONSE TO GROUP B STREPTOCOCCUS Infect Immun. 2009 Mar 30.
• Rhind Nicholas Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR Mol Cell. 2009 Mar 27;33(6):672-4.
• Walsh Kathleen E, Dodd Katherine S, Seetharaman Kala, Roblin Douglas W, Herrinton Lisa J, Von Worley Ann, Usmani G Naheed, Baer David, Gurwitz Jerry H Medication errors among adults and children with cancer in the outpatient setting J Clin Oncol. 2009 Feb 20;27(6):891-6. Epub 2008 Dec 29.
• Guilherme A, Tesz GJ, Guntur KV, Czech MP. Tumor necrosis factor-alpha induces caspase-mediated cleavage of PPARgamma in adipocytes J Biol Chem. 2009 Mar 25.
• Mou Z, Tapper AR, Gardner PD. The armadillo-repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10 J Biol Chem. 2009 Mar 20.
• Hammell Christopher M, Lubin Isabella, Boag Peter R, Blackwell T Keith, Ambros Victor nhl-2 Modulates microRNA activity in Caenorhabditis elegans Cell. 2009 Mar 6;136(5):926-38.
• Padmanabhan Srivatsan, Mukhopadhyay Arnab, Narasimhan Sri Devi, Tesz Gregory, Czech Michael P, Tissenbaum Heidi A A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation Cell. 2009 Mar 6;136(5):939-51. Epub 2009 Feb 26.
• Goldberg Robert J, Spencer Frederick A, Fox Keith A A, Brieger David, Steg Ph Gabriel, Gurfinkel Enrique, Dedrick Rebecca, Gore Joel M Prehospital Delay in Patients With Acute Coronary Syndromes (from the Global Registry of Acute Coronary Events [GRACE]) Am J Cardiol. 2009 Mar 1;103(5):598-603. Epub 2009 Jan 12.
• Croteau Nicole J, Furgason Melonnie L M, Devos Damien, Munson Mary Conservation of helical bundle structure between the exocyst subunits PLoS ONE. 2009;4(2):e4443. Epub 2009 Feb 13.
• Dacwag Caroline S, Bedford Mark T, Sif Said, Imbalzano Anthony N Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation Mol Cell Biol. 2009 Apr;29(7):1909-21. Epub 2009 Feb 2.
• Du Cheng, Jaggi Meena, Zhang Chuanyou, Balaji K C Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin Cancer Res. 2009 Feb 1;69(3):1117-24. Epub 2009 Jan 13.
• Friedline Randall H, Brown David S, Nguyen Hai, Kornfeld Hardy, Lee Jinhee, Zhang Yi, Appleby Mark, Der Sandy D, Kang Joonsoo, Chambers Cynthia A CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance J Exp Med. 2009 Feb 16;206(2):421-34. Epub 2009 Feb 2.
• Hill Joshua S, McPhee James T, McDade Theodore P, Zhou Zheng, Sullivan Mary E, Whalen Giles F, Tseng Jennifer F Pancreatic neuroendocrine tumors: the impact of surgical resection on survival Cancer. 2009 Feb 15;115(4):741-51.
• Duenas-Decamp Maria Jose, Peters Paul J, Burton Dennis, Clapham Paul R Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes J Virol. 2009 Mar;83(6):2575-83. Epub 2009 Jan 7.
• Heilman Susan A, Nordberg Joshua J, Liu Yingwang, Sluder Greenfield, Chen Jason J Abrogation of the postmitotic checkpoint contributes to polyploidization in human papillomavirus E7-expressing cells J Virol. 2009 Mar;83(6):2756-64. Epub 2009 Jan 7.

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