David R. Weaver, Ph.D.
Professor, Department of Neurobiology
Director, Program in Neuroscience
University of Massachusetts Medical School
364 Plantation Street, LRB-723
Worcester, MA 01605
Fax (departmental, shared): 508-856-6266
Faculty page: http://www.umassmed.edu/faculty/show.cfm?faculty=372
My interests related to the Neurotherapeutics Institute fall in three areas:
(1) My major area of interest is the understanding of circadian rhythms in mammals. Circadian rhythms are generated by a known anatomical site, the suprachiasmatic nucleus, and we now know a fair amount about the molecular mechanisms underlying its oscillation. Mouse circadian rhythms have been used as an output/ assay system for demonstrating genetic regulation of behavior, and reversible effects of inducible gene manipulation on behavior, and I believe that this system holds great promise for optimizing transient gene disruption and for assessing the duration of gene therapy in vivo.
(2) I have new research interests in myelination.
(3) Involvement in the Neurotherapeutics Institute will help keep me informed of cutting-edge neuroscience research on campus, which is important to me in my role as Director of the Graduate Program in Neuroscience.
Etchegaray JP, Machida KK, Noton ES, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR (2009). Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29: 3853-3866. (PMCID:PMC2704743).
DeBruyne JD, Weaver DR, Reppert SM (2007) CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nature Neurosci 10: 543-545. (PMCID: PMC2782643)
DeBruyne JD, Weaver DR, Reppert SM (2007) Peripheral circadian oscillators require CLOCK. Current Biology 17: R538-539.
DeBruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM (2006). A Clock Shock: Mouse CLOCK is not required for circadian oscillator function. Neuron 50: 465-477.
Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR (2001). Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30: 525-536.
Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935-941.