Metabolism Core

The Metabolism Core conducts specialized and non-invasive metabolic experiments to measure insulin sensitivity, glucose/lipid/protein metabolism, pancreatic β-cell function, body composition and energy balance. Most experiments are performed under physiological state and in conscious mice. The Core services include:

  • Hyperinsulinemic-euglycemic clamp to assess insulin action in conscious mice (method)
  • Glucose, lipid and protein metabolism in individual organs using radioactive-labeled metabolites in conscious mice (method)
  • Hyperglycemic clamp to assess insulin secretion and pancreatic β-cell function (method)
  • Glucose and insulin tolerance tests (method)
  • Survival surgery of jugular vein cannulation for in vivo experiments (method)
  • Chronic and acute induction of obesity, insulin resistance and diabetes using high-fat diet, lipid infusion, streptozotocin injection and phloridzin treatment (method)
  • Implementation of osmotic pumps or subcutaneous injection for chronic administration of drugs (drug trial study) (method)
  • Non-invasive measurement of food/water intake, energy expenditure, respiratory exchange ratio and physical activity using the metabolic cages (method)
  • Non-invasive assessment of whole body and tissue composition of fat/lean/water mass using 1H-MRS (method)
  • Application of in-house cage wheel for exercise studies


DIRECTOR

Jason K. Kim, Ph.D.
Professor of Molecular Medicine
Professor of Medicine, Division of Endocrinology, Metabolism and Diabetes
508-856-6840 (phone)
508-856-4177 (fax)
jason.kim@umassmed.edu

Jason Kim Photo
CO-DIRECTOR

Dae Young Jung, Ph.D.
Instructor of Molecular Medicine
508-856-8785 (phone)
daeyoung.jung@umassmed.edu

Dae Young Jung Photo

ADDRESS:

University of Massachusetts Medical School
368 Plantation Street
The Albert Sherman Center
9th Floor, Room 1015
Worcester, MA 01605

 

 Overview Mice2