Understanding mechanisms of cellular plasticity that facilitate metastasis
Mechanism of epithelial-to-mesenchymal transition (EMT)
Building novel genetically engineered mouse models to study epithelial plasticity and squamous/basal/quasimesenchymal subtypes in pancreatic cancer progression
Therapeutic vulnerabilities in the metastatic cascade and squamous PDAC subtype
Immune oncology
Defining how tumors mediate host immune suppression
Mechanisms of MDSC mobilization and recruitment to tumors
Finding new therapeutic avenues to synergize with immunotherapies
Cancer cachexia and adipose tissue wasting
Using mouse models to define novel tumor-derived factors that drive pancreatic cancer cachexia
Finding new druggable targets to disrupt tumor-adipose crosstalk